cyclophosphamide will improve the stage or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.
danazol will increase the amount or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.
modafinil will minimize the level or influence of iobenguane I 131 by Other (see comment). Stay away from or Use Alternate Drug. Depending on the mechanism of motion of iobenguane, medications that reduce catecholamine uptake or that deplete catecholamine stores may perhaps interfere with iobenguane uptake into cells, and thus, lower iobenguane efficacy.
levoketoconazole will improve the stage or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
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Repeated administration of modafinil for off-label use, including greater alertness and cognitive-improving consequences in sleep deprivation, can lead to drug tolerance, which suggests which the performance from the drug may possibly lessen after a while.
rifabutin will lower the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Pediatric Suitable scientific tests haven't been done on the relationship of age to the results of modafinil in children youthful than 17 yrs of age. Protection and efficacy have not been founded. Geriatric Even though correct scientific studies on the connection of age to the effects of modafinil haven't been done during the geriatric population, geriatric-distinct complications aren't anticipated to limit the usefulness of modafinil inside the aged.
The benefits of microdosing Modafinil typically are fewer slight Negative effects, much easier time slipping asleep, and the opportunity to take it easy once the work is completed.
Efficacy and protection of adjunctive modafinil procedure on residual excessive daytime sleepiness among nasal steady optimistic airway strain-taken care of japanese clients with obstructive snooze apnea syndrome: a double-blind placebo-managed examine.
modafinil will enhance the degree or effect of citalopram by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Citalopram 20 mg/working day is the utmost proposed dose for sufferers taking CYP2C19 inhibitors as a result of danger of QT prolongation.
modafinil will lower the extent or effect of copyright topical by impacting hepatic enzyme CYP2B6 metabolism. Insignificant/Significance Unfamiliar.
Remember, preserve this and all other medicines out on the get to of youngsters, never share your medicines with others, and use Provigil only for the indication prescribed.
Modafinil is also contraindicated in sure cardiac conditions, such as uncontrolled reasonable to extreme hypertension, arrhythmia, cor pulmonale,[89][ninety] As well as in scenarios with indications of CNS stimulant-induced mitral valve prolapse or remaining ventricular hypertrophy.[ninety one][ninety two] The package insert in the United States cautions about utilizing modafinil in those with a documented professional medical history of remaining ventricular hypertrophy or Those people diagnosed with mitral valve prolapse which have Beforehand exhibited signs or symptoms connected to the mitral check here valve prolapse syndrome even though undergoing treatment method involving central nervous system stimulants.[ninety three] The reasons why modafinil is contraindicated in specific cardiac circumstances are due to the fact modafinil affects the autonomic nervous method and, specifically, exerts substantial effects on autonomic cardiovascular regulation, foremost in a number of people to notable raises in heart level and blood pressure level.